ABSTRACT
Objective:To investigate the effect of antidepressant therapy on cellular immunity and quality of life of patients with depression after thoracoscopic radical resection of esophageal cancer.Methods:Between June 2015 to March 2019, our hospital during the period of line thoracoscope comorbid depressive patients, 186 cases of esophageal cancer radical, according to the indicator method were randomly divided into treatment group and the control group (n=93), the treatment group after surgery for antidepressant treatment, the control group did not give any postoperatively in patients with depressive drugs treatment, routine for psychological counseling. Self-rating Depression Scale SDS and Generic Quality of Life Inventory-74 (GQoli-74) were used to evaluate the changes of depression status and Quality of Life in 2 groups before and after treatment. Flow cytometry was used to detect the levels of CD 4+ and CD 8+ subsets in peripheral blood to evaluate the changes of immune system function in 2 groups before and after treatment. Results:After treatment, the SDS score of the treatment group was significantly lower than that before treatment, the difference was statistically significant( P<0.05), while the SDS score of the control group was not significantly changed before and after treatment, the difference was not statistically significant( P>0.05). After antidepressant treatment, CD 4+ and CD 4+ /CD 8+ levels in the immune system in the treatment group were significantly increased, and CD 8+ levels were significantly decreased, with statistical significance ( P<0.05), while CD 4+ , CD 8+ and CD 4+ /CD 8+ levels in the control group were not significantly changed before and after treatment. There was no significant difference ( P>0.05). After treatment, the body function, psychological function, social function, material state and total score of quality of life of patients in the treatment group were significantly improved compared with before treatment, the difference was statistically significant ( P<0.05), while the score of quality of life of patients in the control group was not significantly changed before and after treatment, the difference was not statistically significant ( P>0.05). Conclusion:Antidepressant therapy can significantly improve the depression status of postoperative esophageal cancer patients, and improve the immune system function and quality of life.
ABSTRACT
Objective To observe the clinical efficacy of acupuncture in regulating depressed state. Method Sixty patients in depressed state were divided into a treatment group and a control group, 30 cases in each group. The treatment group was given basic intervention plus acupuncture, whereas the control group was treated by basic intervention alone. The two groups were evaluated by using Hamilton Rating Scale for Depression (HAMD) and PSTR prior to treatment, and respectively after 1, 2, and 3-month treatment. The clinical efficacies of the two groups were compared. Result The HAMD and PSTR scores were significantly changed respectively after 1, 2, and 3-month treatment compared to that before treatment in both groups (P<0.05). Respectively after 1, 2, and 3-month treatment, the HAMD and PSTR scores of the treatment group were significantly different from that of the control group (P<0.05). Acupuncture worked rather slowly in the first month of treatment, while in the following 2 months, its efficacy increased significantly. The total effective rate was 93.3% in the treatment group versus 40.0% in the control group, and the difference was statistically significant (P<0.05). There were no adverse reactions during the whole intervention with acupuncture. Conclusion Acupuncture is an effective approach in regulating depressed state.